GspM LF DNA polymerase, isolated from Geobacillus sp. M, is functionally equivalent to Bst LF DNA polymerase and can be directly substituted for that enzyme.
GspM2.0 is an engineered variant of GspM that has greatly increased speed. It too can be directly substituted for Bst.
A comparison between GspM, GspM2.0, Bst and Bst2.0 in a fluorescent detection LAMP reaction run on the Genie® II instrument is shown in the figure to the left.